Opinion essay by Maia Szalavitz addresses the need for more helpful and effective prevention strategies in the age of the Fentanyl overdose crisis. The article reviews new harm reduction approaches and prevention strategies in order to better protect youth who are at risk of coming into contact with Fentanyl. It’s a risky time to be experimenting with substances. The PreVenture Program goes to the core of why young people take the risk by focusing on temperament and mental health.